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June 14, 2004
Phytotherapy: A new
anthocyanin-rich berry extract suppresses cancer growth mechanisms
NewsRx.com
A new anthocyanin-rich berry extract suppresses cancer growth mechanisms.
According to published research from the United States, "edible berry anthocyanins possess a broad spectrum of therapeutic and anti-carcinogenic properties. Berries are rich in anthocyanins, compounds that provide pigmentation to fruits and serve as natural antioxidants. Anthocyanins repair and protect genomic DNA integrity. Earlier studies have shown that berry anthocyanins are beneficial in reducing age-associated oxidative stress, as well as in improving neuronal and cognitive brain function."
"Six berry extracts (wild blueberry, bilberry, cranberry, elderberry, raspberry seeds, and strawberry) were studied for antioxidant efficacy, cytotoxic potential, cellular uptake, and antiangiogenic (the ability to reduce unwanted growth of blood vessels, which can lead to varicose veins and tumor formation) properties. We evaluated various combinations of edible berry extracts and developed a synergistic formula, OptiBerry IH141, which exhibited high ORAC (oxygen-radical absorbing capacity) value, low cytotoxicity, and superior antiangiogenic properties compared to the other combinations tested," said D. Bagchi and colleagues, Creighton University, Center for Medicine.
"Antiangiogenic approaches to treat cancer represent a priority area in vascular tumor biology. OptiBerry significantly inhibited both HO- and tumor necrosis factor (TNF)-alpha-induced vascular endothelial growth factor (VEGF) expression by human keratinocytes. VEGF is a key regulator of tumor angiogenesis. Matrigel assay using human microvascular endothelial cells showed that OptiBerry impaired angiogenesis."
"In an in vivo model of angiogenesis, OptiBerry significantly inhibited basal monocyte chemoattractant protein (MCP)-1 and inducible nuclear factor (NF)-kappaB transcriptions. Endothelioma cells pretreated with OptiBerry showed a diminished ability to form hemangioma and markedly decreased tumor growth by more than 50%. In essence, these studies highlight the novel antiangiogenic, antioxidant, and anti-carcinogenic potential of a novel anthocyanin-rich berry extract formula, OptiBerry," Bagchi and coauthors concluded.
Bagchi and colleagues published their findings in Biochemistry - Moscow (Antiangiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Biochemistry-Engl Tr, 2004;69(1):75+).
This article was prepared by Obesity, Fitness & Wellness Week editors from staff and other reports. Copyright 2004, Obesity, Fitness & Wellness Week via NewsRx.com & NewsRx.net.